Whitaker International Fellow, 2007-08
Home Institution: Texas A&M University
Host Country, Institution: United Kingdom, Scottish Centre for Genomics Technology and Informatics
Project Title: An Integrated Approach to Immune Pathways via Microarrays and Novel Imaging Techniques
This study will integrate data from multiple regulatory levels and show an integrated view of infection from the perspective of lipid metabolism. A large-scale investigation of temporal gene expression in macrophages infected with cytomegalovirus (CMV) has revealed CMV infection triggers the down-regulation of a set of genes responsible for cholesterol biosynthesis. The use of reverse phase protein microarray (RPP) technology in combination with fluorescence lifetime imaging (FLIM) and coherent anti-stokes Raman spectroscopy (CARS) in CMV infected macrophages will help unravel molecular events and their phenotypic effects during infection.