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Whitaker International Fellow, 2007-08
Home Institution: Pennsylvania State University
Host Country, Institution: United Kingdom, Queen Mary University of London
Project Title: Mechano-modulation of a Ca2+ Signalling Pathway Controls Chondrocyte Response to Mechanical Loading
Project Abstract:
Mechanical loading plays an essential role in the development of articular cartilage. However, the mechanotransduction pathways that enable chondrocytes to distinguish between loading conditions to activate a range of metabolic events are yet to be elucidated. Intracellular calcium (Ca2+) signaling is a fundamental mechanotransduction component in numerous cell types, but it is unclear whether loading parameters differentially modulate Ca2+ signaling. The proposal will examine the Ca2+ signaling pathway and determine how it is modulated by mechanical loading.
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