Muyinatu Lediju

Whitaker International Fellow, 2009-10

Home Institution: Duke University

Host Country, Institution: United Kingdom, Institute of Cancer Research

Project Title: Ultrasound Guidance of Intensity Modulated Radiation Therapy

Project Abstract:

Intensity modulated radiation therapy (IMRT) is a technique by which radiation doses are modulated to deliver greater intensities to cancerous tumors and less to surrounding tissues. Involuntary motion during IMRT (i.e. respiration, cardiac activity, etc.) may compromise effectiveness. I propose to use ultrasound, which has real-time imaging capabilities suitable for use during IMRT, to track tumor and organ displacements in three dimensions. The 3D motion tracking method will be tested on in vivo organs, such as the bladder and liver. In vivo results will be compared to and validated with tissue-mimicking phantom data, acquired when known displacements are applied during real-time imaging.